The Colombian star scored two goals, including a sensational volley, as the visiting side had a comfortable afternoon.
A superb strike from James Rodriguez helped inspire a dominant Real Madrid to a comfortable 4-0 win over Granada on Saturday.
A brilliant start saw Cristiano Ronaldo give the European champions the lead, slotting home after just two minutes, and Rodriguez added a second with a vicious volley 15 minutes before the break.
Karim Benzema added a third shortly after halftime, coolly poking his effort home following Ronaldo's flick.
Marcelo was denied by the crossbar four minutes later, before Rodriguez took advantage of a defensive mix-up to poke home a fourth and double his tally as Carlo Ancelotti's side followed up last weekend's Clasico triumph in style.
The result represents Real's 11th consecutive win in all competitions, while condemning a toothless Granada to its fifth defeat in six games.
The visitors, who named an unchanged side from the the convincing win over Barcelona, did not take long to assert their authority in Andalucia, with Ronaldo opening the scoring within two minutes.
Some good work down the right saw Daniel Carvajal dispossess Dimitri Foulquier, which allowed Benzema to cut back to the Portugal international inside the area and he marked the 700th match of his career with his 22nd goal of the season.
Granada came into the game having mustered just one win in its last eight matches and posed little threat to Ancelotti's men, who continued to press.
A wonderful clipped ball from Isco allowed Benzema to force a smart save from Roberto in the 23rd minute, before Carvajal blazed his shot over the bar from six yards following Ronaldo's brilliant back-heeled pass.
But the lead was doubled just after the half hour, when a superb sweeping move saw Benzema tee the ball up for Rodriguez inside the area and the Colombian smashed an unstoppable first-time volley into the top corner.
Real's dominance continued in the second half, and the Blancos were celebrating a third just nine minutes after the restart, Ronaldo finding Benzema with another audacious back heel, allowing the Frenchman to beat the offside trap and prod his effort past Roberto.
Granada's goalkeeper was once again a spectator two minutes later and had the crossbar to thank as Marcelo's 25-yard effort was denied.
Rodriguez wrapped up the win three minutes from time by turning home at the far post following some neat play from Ronaldo, capping off a routine afternoon for Ancelotti's charges.