Just one point separates the two teams heading into the final game of the season, with a place in Europe's biggest competition up for grabs.
Freiburg will be without several players for the visit of S04. Key man Daniel Caligiuri will miss out, meaning that Max Kruse will play on the left, with Karim Guede partnering Jan Rosenthal up front.
Pavel Krmas (ankle), Marco Terrazzino (knee) are both out, but Mensur Mujdza could well feature at right back but remains a doubt with a toe problem.
Schalke will be able to welcome back Julian Draxler, who sat out the 2-1 loss to Stuttgart due to suspension, with Raffael dropping to the bench.
Saed Kolasiac is also in line for a return at left back in the place of Christian Fuchs, who has endured a disappointing season. Defenders Christoph Metzelder and Kyriakos Papadopoulos are out, along with wingers Ibrahim Afellay, Tranquillo Barnetta and Chinedu Obasi.
|DID YOU KNOW?|
- Frieburg has recorded 11 wins over Schalke in its Bundesliga history - more than against any other side.
- Only one clash between the two sides at the Mage Solar Stadion has ended all square - a 0-0 draw in February 2010.
- Christian Streich's side has won its last three games at home.
- Schalke star Julian Draxler (pictured, right) is set to make his 75th Bundesliga appearance - he will become the first 19-year-old to reach this figure.
- Jens Keller's side has only taken 19 points on the road this season, just two more than already-relegated Greuther Furth.
- Schalke has conceded 49 goals this season, more than any of the last 14 seasons.