The Real Madrid connection was apparent as Ozil set up the midfielder for the winner as Germany chalked up a first win against the French in more than a quarter of a century.
Marseille's Mathieu Valbuena opened the scoring following Karim Benzema's free kick which cannoned off the bar, before Thomas Muller restored parity soon after the break. Despite the home side dominating, Sami Khedira turned in late to ensure a rare win for die Mannschaft.
In a bright opening from both sides, it was Germany which spurned the best opportunity. Ilkay Gundogan's break saw him pick out Khedira with a fine pass towards the edge of the area, but the Real Madrid star could only drag his shot narrowly wide.
While les Bleus opted for a more cautious approach, die Nationalelf should've broken the deadlock just six minutes from the start amid a ferocious opening. A neat ball threaded into Mesut Ozil from Thomas Muller saw the former denied by a sprawling Hugo Lloris save.
Deschamps' side settled into its rhythm following a frantic opening, dominated by Germany. Nevertheless, the hosts did create a chance of their own, as Newcastle midfielder Moussa Sissoko miscued a shot in a promising position, and Rene Adler - back in the international fold following a two year absence - denying Karim Benzema.
Nevertheless, France was still struggling with the immense counterattacking threat the Germans pose. Lloris was again called into action, turning a Per Mertesacker header onto his own bar and out for a corner as the Germans ascended.
The relentless attacking from both sides continued in a surprisingly open first half. Ribery displayed trickery and pace to evade his marker, before Mathieu Valbuena blazed over. Seconds later, profligate finishing saw Benzema beat the trap, but not Adler who pulled off a monster stop to deny the Real Madrid man.
If the center backs enjoyed a spotless first half, then the wing backs endured a torrid period, with Ribery in particular giving the likes of Mertesacker and Lahm a headache, thought it wasn't long before the game would witness its first goal.
On the stroke of halftime, Benzema's audacious, curling free kick slammed against the crossbar, with the smallest player on the field - Valbuena - heading past Adler to hand the home side the slender of advantages in a thrilling half.
After the break, the Germany was far more conserved, and the new approach paid dividends almost immediately. Substitute Etienne Capoue was the guilty party in conceding possession as Muller struck past Lloris to restore parity after 51 minutes.
Low's side, under the watchful eye of Chancellor Angela Merkel, was once more susceptible to the width offered by Valbuena and Ribery, with the latter spurning a golden opportunity to hand the hosts the advantage following Benzema's sweet cut back.
Despite that, the tenacious Germans would seize the initiative against the run of play. Ozil threaded a sumptuous ball into Khedira, who beat the flag and Lloris to silence the raucous fans inside the stadium before the home side was denied by the flag as Germany held on to confirm victory.