The Fiorentina shotstopper made several smart stops to deny Higuain and Pandev but was helpless to prevent any of the Napoli goals.
The Viola captain looked short of fitness on his return to the side and his eagerness to get forward often left Fiorentina exposed at the back.
The former Manchester City defender struggled to cope with the pace and movement of Napoli's attack and his poor positioning contributed to Insigne's second goal.
The Serbian was burdened with the task of containing Insigne and it was one that he ultimately failed as he allowed the Italian too much time and space to inflict damage.
The Argentine center back found it difficult up against Higuain in the first half though did make a number of crucial headers and tackles to frustrate the Napoli attack.
Looked to expose Napoli's high line with his movement off the ball but ultimately strayed offside too often and struggled to get into goalscoring positions.
A tireless box-to-box performance from the Peruvian midfielder who marked an impressive display with a well-taken goal to reduce Napoli's first-half advantage.
The 29-year-old pulled the strings in the Fiorentina midfield and produced a brilliant goal-line clearance to deny Higuain. However, he struggled to create clear-cut opportunities for his teammates.
The former Liverpool midfielder worked tirelessly in the midfield and was unfortunate to see a goal ruled off for offside.
Though he looked composed on the ball and tidy in possession, Pizarro did not offer sufficient support to the Fiorentina back four as Napoli drove forward from midfield all too easily.
The Slovenian coped well in an unfamiliar lone striker role and although he provided the assist for Vargas' goal with a deft flick. he missed a glorious chance to send the game into extra time when he fired wide in a one-on-one with Reina.
The on-loan Liverpool goalkeeper commanded his area excellently and made himself big in the closing stages to put Ilicic under pressure.
A solid display from the former Real Madrid man who used his experience to keep Ilicic and Rossi quiet.
The Algerian left back looked shaky at times and struggled to contribute to the attack as much as he would have liked.
The Brazilian once again filled in flawlessly at right back, keeping the Viola attack at bay with a number of crucial headers and interceptions.
While he was out of position for Vargas' goal, he showed good reading of the play on the whole to limit the threat to Reina's net.
The Swiss midfielder provided a good shield to the defense and broke up the Fiorentina attack excellently. However, he marred his performance by receiving a needless second yellow card late on.
An impressive box-to-box display from the January signing who proved tidy in possession and offered good support to the back four.
The Napoli captain was the creative hub in the midfield and he demonstrated his leadership by providing the assist for the opening goal.
The 23-year-old will no doubt have impressed Italy boss Cesare Prandelli after an electrifying display. He was a constant threat down the left with his pace and he sent Napoli on its way with two well-taken goals.
The former Real Madrid man was a constant live wire down the right and he got in behind Pasqual on several occasions to set up goalscoring opportunities for his teammates.
'Pipita' was unlucky not to have got on the scoresheet after his early header was cleared off the line. Faded as the game wore on but provided a telling contribution by setting up Insigne's second.
The Chilean looked to give Fiorentina more attacking options from the bench. However, he struggled to penetrate the Napoli back line and rarely tested Reina.
The former Juventus and Milan striker entered the action as a late substitute and he had a major impact, setting up the last-gasp chance for Ilicic.
The Viola top goalscorer made his long-awaited return from the bench but could not make a decisive impact and lacked service.