Roberto Martinez's men will have to cope without Leighton Baines following his broken toe but are unbeaten at Goodison Park so far this season as they welcome the Potters.
The England left back suffered a broken toe in the thrilling 3-3 Merseyside derby against Liverpool on November 23 and will be out for up to six weeks.
Baines's absence leaves a big void for manager Roberto Martinez to fill and the Spaniard says that he will decide who will replace the former Wigan man after running the rule over potential candidates in training ahead of the game.
Everton is unbeaten at home this season but need to start turning draws into wins if the club is to qualify for Europe as it has had to settle for a point in half of its 12 games so far this season.
Martinez's charges are unbeaten in five games and will be boosted by the inclusion of defender Antolin Alcaraz in the squad after he came through 45 minutes of a behind-closed-doors game against Sheffield Wednesday.
The Paraguay international has not played for the Merseyside outfit since his move from Wigan in July due to a hamstring injury but could make his debut against Stoke while striker Arouna Kone and midfielder Darron Gibson are long-term absentees due to knee injuries.
Nikica Jelavic has been linked with a move away from Goodison Park but Martinez insists that the striker still has a part to play at the club.
"[Speculation] doesn't surprise me because obviously Nikica Jelavic is a terrific player to have, he's a goalscorer and you don't get them easily in the game," the Toffees boss told reporters.
"From our point of view he is very important and he needs to be ready to help the team when the opportunity arises, which could be very soon."
Stoke heads into the game buoyed by a 2-0 home victory over struggling Sunderland. Mark Hughes's side is unbeaten in its last three top-flight games but has only won once on its travels in the league and that was at West Ham back in August.
Defender Robert Huth (knee) and midfielder Marko Arnautovic (hamstring) have been ruled out of the trip to Goodison Park but midfielder Stephen Ireland (shin) is back in contention.