The game was stopped in the 11th minute as players and fans paid their respects to Ecuador striker Christian Benitez, who died last month, while Santi Cazorla scored the clincher
Goals in either half for Alvaro Negredo and Santi Cazorla saw Spain post a relatively comfortable 2-0 friendly win over Ecuador on Wednesday.
The world and European champions dealt with the altitude in Guayaquil and produced a professional win despite the absence of several of their stars.
Negredo's flick in the 25th minute set Spain on its way before Cazorla, who made the most of a rare start, sealed the triumph in the second half.
None of Xavi, Juan Mata, Fernando Torres or Gerard Pique were involved in South America for Spain, but Del Bosque did give new Manchester City signing Negredo a chance to lead the line up front.
Ecuador picked a strong side that relied heavily on the attacking instincts of Felipe Caicedo and Joao Rojas, but it was quickly on the back foot.
Spain was inches away from scoring after just three minutes as it carved open the Ecuador defense with a trademark passing move before Silva saw his effort hit the bar.
Negredo volleyed over shortly after, before players and fans stopped during the 11th minute to pay their respects to Christian Benitez, who wore the same number for Ecuador.
The striker died last month of heart failure, aged just 27, and his memory was warmly applauded while the capacity crowd sung his nickname – 'Chucho' – loudly.
Andres Iniesta hit the post in the 22nd minute with a 20-yard effort from distance and it was a warning sign Ecuador did not heed.
Just three minutes later – after Caicedo wasted a free header - Negredo put Spain into the lead, producing an outrageous backheel flick after sublime build-up work from Cazorla.
At the other end, Gabriel Achilier nodded a free-kick wide while Segundo Castillo forced a good save from Iker Casillas from 20 yards, but Spain was well worth its halftime lead.
Del Bosque removed Negredo, Iniesta and Silva at the break, with Thiago Alcantara, Jesus Navas and Fernando Llorente introduced in their place.
Ecuador slowly worked into the match and it should have equalized in the 61st minute, but Enner Valencia hit the crossbar with a header.
Spain then delivered the sucker punch as Cazorla benefited from Cristian Tello's neat flick before surging into the penalty area and driving a right-footed finish past Maximo Banguera.
Ecuador had a few half-chances to pull a goal back but lacked quality in the final third, while Llorente nodded wide from a Navas cross when he should have done better.
Spain deserved victory, though, with a disciplined and organized performance that will be sure to please manager Del Bosque.
For Ecuador, the result was far from ideal, with crucial 2014 World Cup qualifiers against Colombia and Bolivia next month.