The Russians play host at Zenit St Petersburg's ground - due to the state of their own pitch - against a team which suffered the same fate on matchday one.
The game will take place in Zenit St Petersburg's Petrovsky Stadium due to the state of the pitch at CSKA's Arena Khimki and both sides will be looking to get their first points of the campaign following defeats on the opening matchday in group D.
CSKA lost 3-0 away at Bayern Munich, while Plzen went down by the same margin at home to Manchester City.
Both sides will be aware of the importance of this game if either is to qualify for the second round or, at worst, finish third and earn a spot in the last 32 of the Europa League.
The home side has used Zenit's stadium on 12 occasions in the past 10 years with mixed results, winning five and losing five of those matches.
Pavel Vrba's Plzen has been much more consistent on its travels and arrives in Russia on the back of a seven-match unbeaten run – including five wins – on the road in Europe.
CSKA's only previous meeting with Czech opposition came three years ago when the club earned four points from its matches against Sparta Prague in the Europa League group stage.
Leonid Slutsky's side is winless in its last three Russian Premier League games, including Saturday's 2-0 reverse away at Terek Grozny, and the club currently sits in fourth place, five points adrift of Zenit.
Alan Dzagoev and Seydou Doumbia are doubts with hamstring injuries, while Aleksandrs Cauna will be out until November with a fractured toe.
CSKA will be hoping for a change in fortunes in front of goal, as the club has gone 279 minutes without scoring in all competitions.
Plzen, unbeaten after 10 games in the Czech Liga, had suffered a similar goal drought - 272 minutes - until Frantisek Rajtoral's opener in Friday's 2-1 win at Vysocina Jihlava. That result left Vrba's side in second, four points behind Sparta.
The manager revealed that David Limbersky is a major doubt for the game after sustaining a thigh injury on Friday, while defender Radim Reznik returned in the same match and could feature.