The Eagles secured back-to-back wins at Selhurst Park with victory over the Bluebirds, as the London side's strike partnership continues to thrive under the former Stoke boss.
Cameron Jerome, once of Cardiff, gave the home side an early lead, powering a header into the back of the net after good work down the flank from Jason Puncheon, before Marouane Chamakh doubled the Eagles' lead with a confident finish.
The result gives Palace its first back-to-back league victories of the season as the resurgence under new manager Tony Pulis continues, while the Bluebirds are now winless in five.
Pulis made no changes to the side that beat West Ham 1-0 on Tuesday night, with former Cardiff duo Danny Gabbidon and Jerome included in his starting XI, while Kim Bo-Kyung came in for Aron Gunnarsson in the Cardiff's only alteration from Wednesday's goalless draw at Stoke.
Cardiff was quick out of the blocks as an unmarked Fraizer Campbell got his head to a Don Cowie cross from the right in the second minute, but should have done better as Julian Speroni pushed the ball behind for a corner.
However, it was Palace which broke the deadlock four minutes later, with Jerome netting against the club he left in 2006. Puncheon chipped the ball into the six-yard box and Jerome sent a downward header beyond a flailing David Marshall, ending his 21-game goal drought.
Palace continued to put pressure on the Cardiff defense, with Barry Bannan sending an effort high and wide of the target from the edge of the penalty area as he aimed to double his side's tally.
As Cardiff struggled to cope with the home side's high-tempo start, Gary Medel drilled a shot from distance wide of the right-hand post in the 29th minute.
Joel Ward stormed forwards on the stroke of halftime, exchanging passes brilliantly with Mile Jedinak, but his eventual effort was deflected wide for a corner.
Palace continued to look threatening after the break, with Puncheon driving wide of the right-hand upright from 25 yards three minutes into the second period, before Jerome forced Marshall into a diving save – his low driven effort tipped around the post by the Scot.
But the Palace pressure paid off as Chamakh doubled the home advantage in the 57th minute, when Ben Turner's attempted clearance fell kindly for the Moroccan, who fired a right-footed shot into the bottom right-hand corner of the net.
Goal-line technology was put to the test in the 69th minute as Marshall scrambled a Jerome header off the line, with replays suggesting the majority of the ball had crossed the line, although not enough to make it 3-0.
Jerome's inspired performance continued as he directed a left-footed strike narrowly wide of the target 10 minutes from time, while his former employer barely threatened as Cardiff left London empty handed.