Jose Mourinho's men got back to winning ways against Schalke in the Champions League on Wednesday, but will now be looking to put their domestic title challenge back on track.
Jose Mourinho's side slipped five points behind Arsenal in the last round of fixtures courtesy of a 2-0 defeat at Newcastle.
A much-changed Chelsea lineup responded with a 3-0 victory over Schalke in the Champions League on Wednesday, and Mourinho will be keen to oversee another win with Arsenal not in action until Sunday.
West Brom has picked up just three victories from 10 league fixtures so far this season, but brought an end to a three-match winless streak by triumphing 2-0 over managerless Crystal Palace.
The team's last victory at Stamford Bridge came back in January 1984 and it has been 35 years since West Brom recorded an away league win over the Blues.
Demba Ba scored the winner the last time the two sides met in west London, in March, and may fancy his chances of breaking into the starting XI this time around, with Fernando Torres (thigh) a doubt.
The Senegalese striker did his selection hopes a world of good with a goalscoring cameo from the bench against Schalke.
However, the man he replaced on Wednesday night - Samuel Eto'o - scored the other two goals and is likely to lead the line.
Eden Hazard should also return to the fold after missing the midweek European clash as punishment for missing a training session, but Marco van Ginkel (knee) is a long-term absentee.
Steve Clarke, meanwhile, has a long list of players on the treatment table, although Victor Anichebe (hamstring) has a chance of returning.
Billy Jones (hamstring), Ben Foster (foot) and Zoltan Gera (knee) are all set to miss out, while Scott Sinclair (hamstring) and Nicolas Anelka (groin) face late fitness tests.
"Scott has done a little bit of training this week," Clarke told reporters. "If I'm being honest, this game might come a little bit too early for him to be in the starting XI.
"Nicolas is doubtful because he has a slight groin strain."