An own goal by John Terry saw the Eagles run out shock 1-0 winners last weekend, prompting the Blues manager to rule out his side winning the Premier League this season.Two defeats in five days have dealt a major blow to Chelsea's quest for silverware and the club can ill afford another setback versus Stoke City.
The London club slumped to a 3-1 Champions League quarterfinal first-leg defeat against Paris Saint-Germain at Parc des Princes on Wednesday, on the back of a shock 1-0 Premier League loss at Crystal Palace.
The Portuguese may have to wait at least another year to become the first manager to win Europe's premier club competition with three different sides and the domestic top-flight title may also elude him in his first season back in England.
Mourinho also expressed frustration with his side's lack of firepower after he employed Andre Schurrle in an unfamiliar role as a striker before bringing on Fernando Torres in the second half.
Torres has scored just nine goals this season and one in his last 11 appearances, while Demba Ba has rarely featured under Mourinho and appears to be on his way out of Stamford Bridge.
Samuel Eto'o has been sidelined with a hamstring injury and Chelsea will be hoping the Cameroon international is fit enough to return against Stoke as the team strives to get its push for the title back on track.
Chelsea is now second in the table with six top-flight games remaining, two points behind Liverpool and the same margin clear of Manchester City - which has two games in hand.
The Stamford Bridge outfit suffered a 3-2 defeat at Stoke back in December before gaining revenge with a 1-0 FA Cup victory against Mark Hughes' side the following month.
The defeat at relegation-threatened Palace led Mourinho to question the mentality of some of his players, and they will have to be up for the battle against a Stoke side which heads to the capital in fine form.
A 1-0 victory against Hull City last weekend stretched Stoke's winning run to three matches and the club is now unbeaten in its last five - a sequence of results that has seen the team move up to 10th.
Stoke has a poor record at Chelsea, though, losing the last seven games at Stamford Bridge and failing to score in the last six visits.
Brazil midfielder Ramires will not feature for the home side once again as he completes a three-match ban, while Eto'o's fitness will be monitored ahead of the game and it remains to be seen if Ashley Cole (knee) will return to the squad.
Stoke, meanwhile, will be the injured Robert Huth and Oussama Assaidi (both knee).