The west London side was easily beaten by the Ukrainians on the third matchday and Mircea Lucescu's dark horses have failed to win just one game so far this season.
Ivanovic, Cahill, Luiz, Cole
Oscar, Mata, Hazard
Srna, Chygrynskiy, Rakitskiy, Rat
Willian, Mkhitaryan, Teixeira
Roberto Di Matteo could be boosted by the returns of David Luiz (ankle) and Juan Mata (hamstring) after the pair were forced to sit out the weekend draw against Swansea City.
Frank Lampard's absence through a calf injury is set to go on, the midfielder having picked up the problem in the tie between these two sides at the Donbass Arena on Matchday 3.
John Terry is available for the game but Di Matteo has admitted that he may not play the skipper, who has just completed his four-game domestic ban for racially abusing Anton Ferdinand.
The Ukrainian side has a full-strength squad to choose from with no injury concerns, so Dmytro Chygrynskiy may come into the side after missing the first game between the two teams.
|DID YOU KNOW?|
- Chelsea has not lost a home tie in the Champions League since a 1-0 semifinal first-leg defeat to Manchester United on April 6, 2011.
- If selected, Branislav Ivanovic will be making the 300th appearance of his career.
- The Blues have been in fine form at home this term, with just Juventus and Manchester United avoiding defeat at Stamford Bridge.
- Shakhtar has maintained its 100 percent winning record in the Ukrainian league this season - Juventus is the only side to have avoided defeat against them so far.
- Henrik Mkhitaryan (pictured right) is the top goalscorer in Europe's major leagues with 14 goals in 13 games so far this season.
- If Chelsea manages to score, it will be the 100th goal that Shakhtar has conceded in Europe under Mircea Lucescu.