Yoan Gouffran and Loic Remy saw Alan Pardew's side triumph 2-0 in November, but both players are unavailable as the club looks to bounce back from a derby defeat.
Branislav Ivanovic's first-half strike Monday ended City's unblemished home record in the top flight and moved the club level on points with Manuel Pellegrini's second-place side.
West Ham frustrated Mourinho's charges by holding on for a goalless draw in the last game at Stamford Bridge and England defender Gary Cahill is aware his team can ill-afford to drop points against Newcastle.
He said: "No disrespect to West Ham, we had loads of possession. We spoke about that after the game and that was a blow to stuff two points up at home.
"We're now on the positive end of a great win away from home, so we can't afford to throw that away at the weekend against a tough team. We're home again - we should be buzzing with confidence and ready to go again."
Chelsea also has the incentive of exacting revenge over Alan Pardew's side, which beat it 2-0 at St. James' Park in November.
Newcastle has triumphed in three of its last four games against Chelsea, but travels to the capital on the back of a dismal 3-0 derby defeat at home to rival Sunderland.
It would be a major surprise if Newcastle pulled off another victory at the end of a week in which director of football Joe Kinnear resigned. The club has won just one of its last seven matches and the departure of influential midfielder Yohan Cabaye to Paris Saint-Germain was a major blow.
Leading scorer Loic Remy will play no part at Stamford Bridge as he serves the second game of a three-match ban following his red card at Norwich City.
Midfielder Cheikh Tiote is a doubt after sustaining an injury in training this week, while Pardew will also check on striker Papiss Cisse (back). Yoan Gouffran (muscular injury) and Gabriel Obertan (knee) could both return, but defender Fabricio Coloccini (knee) is set to miss out again.
Chelsea will once again be without Fernando Torres (knee), so either Samuel Eto'o or former Newcastle striker Demba Ba will lead the line.