Luis Enrique will be determined to prevent the Blaugrana from grabbing three points following their Clasico victory over Real Madrid.
Barcelona will look to carry momentum from its triumph against Real Madrid into Tuesday's visit to the Estadio de Balaidos to face Celta Vigo.
Gerardo Martino's side continued its unbeaten start to the Liga campaign as Barca saw off the challenge of its Clasico rival Saturday with a 2-1 victory at Camp Nou in the marquee fixture. A goal in either half from Neymar and Alexis Sanchez put Barcelona into a commanding lead before Jese Rodriguez's consolation effort for Carlo Ancelotti's side in injury time.
That result took the Catalan giants' record to nine wins and one draw from their 10 Liga fixtures, meaning the defending champion heads into Tuesday's game on top of the table, one point ahead of Atletico Madrid and six clear of Real.
Martino may use the game as an opportunity to once again rotate his squad, as the Celta fixture marks the second of three matches that Barcelona will play in seven days.
The likes of Alexis, Pedro and Carles Puyol were all named on the bench against Real and Martino could utilize his squad in order to keep them fresh, with a league clash against Espanyol on Friday on the horizon.
Key to Barca's success could be the form of Brazilian winger Neymar after his starring role in his first Clasico appearance, when the 21-year-old scored to take his Liga tally to three goals this season.
Lionel Messi will also be keen to make an impact against Celta, after failing to hit top form against Madrid. Martino is without fullback Jordi Alba (hamstring) and midfielder Jonathan dos Santos (knee).
Barcelona will be wary of an upset, having drawn the corresponding encounter between the two sides 2-2 last season. Luis Enrique's side has endured a difficult start to the season and sits in 16th place with just nine points from 10 games.
Celta, though, will be buoyed by a 5-0 rout of Malaga on Saturday, a victory that ended a run of seven league games without a win, including four straight defeats prior to facing Bernd Schuster's side.
Denmark international Michael Krohn-Dehli could come back into contention following a sprained ankle, although former Barca star Enrique may opt for the same starting XI that comfortably saw off Malaga.