Diego Simeone's side is two pints adrift of second-place Barcelona and three behind leader Real Madrid going into the weekend.
Atletico Madrid has fallen to the bottom of the pile in the three-way chase for the Liga title but will want to keep pace by beating Celta Vigo.
Diego Simeone's men sit third in the Spanish top flight, two points adrift of second-place Barcelona and three points behind city rival and leader Real Madrid.
However, Atletico's title charge has waned in recent weeks as it has picked up just one win from its last four league fixtures, while it also conceded a late equalizer to miss out on victory against Real on Sunday.
Saturday's trip to Vigo marks the beginning of a series of very winnable fixtures for the men from the Spanish capital, who face Espanyol, Real Betis and Granada before the end of March.
Atleti picked up a 2-1 win when the sides met in Madrid in October and is unbeaten in the last five meetings between the two.
Atleti is without fullback Javier Manquillo (neck), who has taken his first steps toward making a return to training, while defender Rafinha (toe) is a doubt for the hosts and forward Mario Bermejo (thigh) could be back in contention.