Michael Laudrup's side is unbeaten in its last four matches in all competitions, while Malky Mackay's men have not registered a league win since the end of September.
Swansea is now into its third Premier League campaign, while Cardiff secured promotion last season as the winner of the Championship.
The sides last faced each other during the 2010-11 season, with both meetings finishing 1-0 in favor of the away team.
Cardiff has home advantage this time around, but is winless in three since a 2-1 triumph over Fulham in September.
Malky Mackay's men have also mustered only one goal at the Cardiff City Stadium since defeating Manchester City 3-2 in their first Premier League home game.
By contrast, Swansea will be looking to extend its unbeaten run in all competitions to four games.
Mackay has attempted to play down the significance of Swansea's visit, but recognizes how much victory would mean to either club.
"It's only three points. It's another Premier League team coming to the stadium, but there is a lot of importance attached to the game," he said.
Mackay's opposite number, Michael Laudrup, is aware Swansea's supporters will be demanding a strong showing.
"As a player and as a manager, you feel how important it is to the fans, and you know for yourself that it's a different game," said Laudrup. "Even if you have games before the derby, people are already talking about this game."
Striker Andreas Cornelius (ankle) remains Cardiff's only absentee.
Swansea's Pablo Hernandez has suffered a recurrence of a thigh injury, while fullback Ben Davies remains sidelined with an ankle problem.
However, midfielder Jonjo Shelvey is available once again after missing the draw with West Ham due to a tight hamstring.
Although just two points separate the two teams, Swansea currently sits ninth in the Premier League, while Cardiff is 16th.