The teams come into the game in Toronto on the back of impressive victories over Honduras and England, respectively.
Chile has not beaten Brazil in its last 11 attempts, with the five-time World Cup winners taking eight of the last nine meetings between the sides.
Luiz Felipe Scolari's men will be confident of extending their unbeaten run against Chile, having won their last five matches, conceding only once in the process.
After clinching the Confederations Cup in June, Scolari's side tasted defeat in Switzerland before going on to rack up wins against Australia, Portugal, South Korea, Zambia and, most recently, Honduras.
Five different players - Bernard, Dante, Maicon, Willian and Hulk - got on the score sheet in Brazil’s 5-0 win at the weekend. However, Brazil is likely to face its toughest test in recent months when it takes on a Chile side that is unbeaten in 10 straight and has the in-form Alexis Sanchez in its ranks.
The Barcelona forward has 10 goals in as many games for club and country after scoring twice in Friday's 2-0 win over England at Wembley. His last three appearances for Chile have produced five goals and the 24-year-old believes his country could yet achieve something special in next year’s World Cup in Brazil.
"We have to believe that Chile have a chance. It is not a home tournament but we must take advantage of it being in South America," Sanchez told The Daily Express. "We will not have to adjust to the conditions as much as other nations."
Fans at the Rogers Centre could well be in for an entertaining affair, with goals seemingly on the menu.
The last eight fixtures between the two sides have all featured at least three goals, with Brazil alone managing three or more in all but one of those encounters.