Jurgen Klopp's side lost both encounters to Hamburg last season, including a 4-1 defeat at Signal Iduna Park, and he will be determined to ensure there will not be a repeat.
Borussia Dortmund will look to extend its perfect start to the Bundesliga season when it hosts Hamburg on Saturday.
Jurgen Klopp's side has started the new campaign brilliantly, posting victories in all four of its league fixtures. New signings Pierre-Emerick Aubameyang and Henrikh Mkhitaryan have slotted in seamlessly, scoring five Bundesliga goals combined, and Klopp's men look like a serious threat to reigning champion Bayern Munich this season.
Dortmund's defense has also been in form, conceding just two goals in the four fixtures, and the club will head into Saturday's match brimming with confidence.
BVB could be missing Polish forward Robert Lewandowski, though, with the 25-year-old returning to Germany early after suffering an injury while on international duty. Lewandowski hurt his knee in a World Cup qualifier against Montenegro on Friday, and had to pull out of Tuesday's fixture against San Marino as a result.
The striker, who scored 36 goals in all competitions for Dortmund last term, was diagnosed with tendonitis in his left knee by his club's medical staff. Also in doubt for Dortmund are Marco Reus (gastroenteritis) and Marcel Schmelzer (facial injury).
Mkhitaryan may play more of an advanced role if Lewandowski misses out, with the Armenia international scoring twice in Dortmund's last match, a 2-1 win at Eintracht Frankfurt.
Hamburgm conversely, has started the season slowly, registering just one win from the first four matches, leaving the club 12th in the table.
That lone victory came in the last match, a 4-0 trouncing of newly promoted Eintracht Braunschweig, and Hamburg will not fear its high-flying opponent, especially after having success against BVb last season.
Hamburg did the Bundesliga double over Dortmund last term, following up a 3-2 home win in September with an outstanding 4-1 victory on the road in February. Despite conceding an early goal, Hamburg came from behind to win as Heung-Min Son, who moved to Bayer Leverkusen in the summer, and Artjoms Rudnevs scored doubles.
Hamburg captain Rafael van der Vaart is in doubt for the clash with a thigh strain that ruled him out of the Netherlands squad, with coach Thorsten Fink admitting it was unlikely that he would feature. Van der Vaart's absence may give Turkey international Hakan Calhanoglu a chance to shine, though.
The 19-year-old made his international debut on Friday in Turkey's 5-0 World Cup qualifying win over Andorra, while he also scored twice off the bench – after replacing Van der Vaart – in Hamburg's recent 4-0 triumph.