Jurgen Klopp's men are four points behind Bayer 04 and will be wanting to keep the pressure up with another victory over Saturday's visitor.
Borussia Dortmund will renew Bundesliga rivalries with Eintracht Frankfurt on Saturday, five days after eliminating the club from the DFB-Pokal.
The meeting will be the side's second in the week, following Tuesday's Pokal quarterfinal, which Dortmund won 1-0 thanks to Pierre-Emerick Aubameyang's 83rd-minute strike.
After a strong start to the season, Jurgen Klopp's side has suffered a woeful downturn in form, a run of three wins from the last nine games has left the club 17 points adrift of league leader Bayern Munich.
Having made last season's Champions League final, only to be beaten by Bayern, Dortmund's quest to reach the showpiece again will continue with a round-of-16 tie against Zenit St Petersburg - the first leg of which takes place on Feb. 25.
The club cannot afford to become sidetracked though, with Schalke and Borussia Monchengladbach breathing down its neck in search of the third and final automatic Champions League qualification berth.
Saturday provides Dortmund an opportunity to improve its recent wretched home form, with just one point taken from the past four matches at Signal Iduna Park.
Frankfurt has suffered a similarly miserable run on its travels, with just one win on the road in the last seven league games, although that did come at second-placed Bayer Leverkusen back in December.
Sven Bender and Marco Reus are doubts for the game with thigh injuries, although Klopp hinted on Thursday that they could be involved.Frankfurt finished sixth last season, earning a spot in the Europa League, though the added commitments may have hindered the team and it is currently 12th, only four points off the relegation playoff spot.
The task against Dortmund will not be made any easier by the loss of captain Pirmin Schwegler, who suffered cracked ribs in last weekend's win over Eintracht Braunschweig.