Jurgen Klopp, who is set to become his club's longest-serving coach, could be without 10 first-team players for the game at Signal Iduna Park.
Borussia Dortmund is braced for a difficult start to the Bundesliga season in what will be landmark clash with Bayer Leverkusen for the club's current coach.
BVB boss Jurgen Klopp will become his team's longest-serving coach when he takes charge of Saturday's game at Signal Iduna Park, having been at the helm since 2008.
The charismatic 47-year-old tactician is set to break Ottmar Hitzfeld's record tenure at Dortmund and there will be a sellout crowd to mark the occasion for a mouth-watering first league game of the 2014-15 campaign.MORE: Balotelli in photos | Done deals | Hottest WAGs
Dortmund finished 19 points behind champion Bayern Munich last season and has since lost striker Robert Lewandowski to its Bavarian rival.
However, the club has added Adrian Ramos and Ciro Immobile to its ranks to replace the Poland striker and will be buoyed by its 2-0 DFL-Supercup win over Pep Guardiola's men last week.
On the injury front, Nuri Sahin (knee) is closing in on a return, but the game is expected to come too soon for the midfielder.
Oliver Kirch (thigh) and Ji Dong-won (hamstring) will play no part after suffering injuries in training this week, but Erik Durm (illness) should be available.
Lars Bender could make a welcome return for the visitors after recovering from a thigh injury, while Kyriakos Papadopoulos is also in contention to make his debut following his loan move Schalke.