The Bavarians retained their league title in record time on Tuesday and their visitor may sense an opportunity to seize advantage of a post-celebration hangover.
Hoffenheim will hope to take gatecrash Bayern Munich's Bundesliga party on Saturday.
Pep Guardiola's men completed their title defense on Tuesday with a 3-1 win over Hertha Berlin as goals from Toni Kroos, Mario Gotze and Franck Ribery saw the club over the line in record time.
Bayern wrapped up a 24th league championship with seven games to spare and will now attempt to avoid defeat in the run-in to become the first side in Bundesliga history to enjoy an unbeaten campaign.
The Bavarians need 14 points to match the division's record points total, which they set last season, and will be strong favorites to add to their tally this weekend as they go in search of a 20th straight win.
Hoffenheim would appear to have little left to play for. Back-to-back wins - the latest coming against Hannover in midweek - have countered two previous losses and given the club a lift, but its outside hopes of a top-six finish still look to have faded.
If the club is to register an unlikely victory against Guardiola's men it will likely need a superhuman defensive effort, having shipped 15 goals in the last six games - keeping just one clean sheet in the league this term.
Bayern, meanwhile, is one goal away from 80 in the top flight this season and is close to setting a new record for the fewest conceded in a Bundesliga campaign.
The current record, set by FCB, stands at 18, with Manuel Neuer and backup Tom Starke - with a single appearance against Hannover in February - conceding just 13 this term.
Neuer is also five clean sheets away from matching last season's record of 21, again set by Bayern.