Pep Guardiola's men won 7-0 last weekend against Werder Bremen and in their last three encounters against Saturday's visitor the club has scored 20 and conceded two goals.
Bayern Munich hosts Hamburg on Saturday after suffering only its third defeat of the year in midweek and may take its frustrations out on a side it has put a barrage of goals past in previous encounters.
In the last three visits to the Allianz Arena, Hamburg has conceded 20 goals, including a ignominious 9-2 thrashing last time around.
Saturday will see Bayern crowned as Herbstmeister (Autumn Champion) that would end the week on somewhat of a high given the disappointment against Manchester City on Tuesday.
Manuel Pellegrini's men produced a stunning comeback to win 3-2 in Bavaria in the sides' final Champions League Group D clash, but the score line was not enough to knock Pep Guardiola's men off top spot in the pool.
The loss will have been doubly galling for Guardiola, having seen his side race into a two-goal lead in just 12 minutes.
Heading into the game, Bayern had won its previous 10 Champions League matches - a tournament record - and secured victories in each of its 19 fixtures at the Allianz.
The club is 40 unbeaten in the Bundesliga, and had lost just twice previously in 2013 - to Arsenal in the Champions League in March and Borussia Dortmund in the DFL-Supercup in July.
Attacker Thomas Muller believes the City defeat proved Bayern is not invincible - but challenged his colleagues to use it to inspire them to get back to winning ways at the weekend.
"The normal human in all of us came to the surface," the Germany international said. "We were too casual. We made a great start but let them back into it. We need to regain our utter desire to win."
Hamburg has not beaten Bayern away from home since April 2007, and the club's recent form has been patchy with three defeats in its last six outings.
Former Netherlands coach Bert van Marwijk has overseen four wins from his 10 games in charge since replacing Thorsten Fink in September - only lifting the club from 15th to 13th in the process.
Despite the stagnating progress, former Bayern fullback Marcell Jansen is not prepared to head to Bavaria with damage limitation in mind.
He told Hamburg's official website: "Bayern follow a clear concept and will do the same against us. We all have to play to our limit and everyone in the team must defend well.
"As a player you have to believe in your chance, otherwise there is no point in going there. That is how we will be approaching the game."
First-choice goalkeeper Rene Adler is a doubt having struggled with an ankle injury in the week, while Ivo Ilicevic has also been missing due to personal reasons.
Captain Rafael van der Vaart returned to training on Tuesday, however, after recovering from an ankle injury and off-field issues.
Bayern will be without long-term absentees Arjen Robben, Holger Badstuber (both knee) and Bastian Schweinsteiger (ankle), but has been boosted by recent returns of Xherdan Shaqiri and Claudio Pizarro.