The Blaugrana stormed to the Liga title last term and start their defense at Camp Nou, though Lionel Messi is a major doubt as they enter the new season.
Lionel Messi remains a serious injury doubt as Barcelona gets its La Liga title defense under way at home against Levante on Sunday.
The 26-year-old Argentine star suffered a minor thigh strain during the Spanish champions' preseason tour of the Far East, an injury that kept him out of Argentina's 2-1 win over Italy in Rome on Wednesday.
Messi has undergone rehabilitation training with Barcelona's medical personnel in a bid to be fit for selection in Gerardo Martino's first competitive fixture in charge, but with a hectic schedule in the next two weeks, which includes a two-leg Supercopa de Espana final with Atletico Madrid on August 21 and 28, Martino may decide to rest his star player.
Manchester United target Cesc Fabregas is also doubtful after he sprained his ankle in the club's 3-1 preseason victory over a Malaysia XI on Aug. 10.
Nevertheless, history is on the side of Martino - who took over from Tito Vilanova last month - as six of Barcelona's eight previous managers have tasted success in their first league match, with only Pep Guardiola losing in a 1-0 defeat away to Numancia in 2008.
And the new boss could hand a competitive debut to Brazil international Neymar, who signed from Santos in May in a move worth around $75 million.
Levante has never won at the Camp Nou, but it was unlucky in its last visit when a late Fabregas goal consigned them to a 1-0 defeat on April 20.
After a sixth-placed finish and subsequent UEFA Europa League qualification in 2011-12, Levante slipped to 11th last time around. In a bid to improve on that performance, the club brought in Joaquin Caparros to replace former manager Juan Ignacio Martinez.
And Caparros has been busy in the transfer window so far, bringing in the likes of forward David Barral from Orduspor, midfielder Jordi Xumetra from Elche and goalkeeper Javi Jimenez from Murcia.
The new manager may not be able to call on the services of Ruben Garcia and Papakouli Diop at the Camp Nou, though, as both are struggling for fitness.