Diego Simeone's men have made a strong start to life in the Champions League and will be confident of landing a comfortable victory in Austria.
Diego Simeone's side went down 1-0 at Espanyol on Saturday, the first Liga fixture the team had failed to win since May, a run stretching nine games.
Atletico goes into the clash in the Austrian capital facing a Vienna side which has not won in five games, a run that began with a shock 2-1 loss to third-tier Kalsdorf in the OFB Cup.
Atleti has six points from its opening two games to top Group G, while Vienna is third after grabbing a point away to Zenit in the last round of fixtures.
Nenad Bjelica's side now stands in the way of a third straight Champions League win for the visiting side, a feat the club has not achieved since the 1958-59 edition.
However, the omens do not look good for former Betis midfielder Bjelica.
Vienna has won just one of nine previous home ties against Spanish opposition, while Atleti won the only previous meeting between the two clubs - a first-round European Cup tie in 1970.
Recent form may encourage the club, though, with the Austrian champion having kept clean sheets in four of its six continental games this term, only narrowly losing to Porto on matchday one.
Alex Grunwald (knee) remains a long-term absentee for the home side and has been joined in the treatment room by Alexander Gorgon, who underwent knee surgery over the weekend and is expected to miss the remainder of the season.
Miranda (calf) and and Leo Baptistao (ankle) are unlikely to feature at the Ernst Happel Stadion, while Josuha Guilavogui and Oliver Torres missed the weekend trip to Espanyol, putting their involvement in doubt.