Atleti can record first league double over visitors in 63 years against Carlo Ancelotti's men on Sunday but will be up against it with los Blancos brimming with confidence
On that occasion, Atleti went on to claim the Liga title and Diego Simeone will hope that proves to be a positive omen in an ever-intriguing battle for this year's championship.
Real tops the pile in La Liga with 63 points going into the fixture, just three above Gerardo Martino's Barcelona and the Rojiblancos, who sit second and third respectively.
Simeone's men triumphed 1-0 in the reverse fixture last September thanks to Diego Costa's goal, meaning Atleti can end a 63-year wait for a league double on Sunday.
To do so, Atleti will have to end a run of six successive league defeats to its arch rival onits own patch and claim a first home Liga triumph over the Bernabeu outfit since a 3-1 victory in 1999.
Simeone can take confidence from an unbeaten home league record this season, but the most recent encounters between the two sides saw Real cruise to a 5-0 aggregate victory in the Copa del Rey semifinals in January.
That win went a long way to avenging the extra-time defeat to Atleti in last year's Copa final and Carlo Ancelotti's men have been in supreme form in La Liga recently.
The last time the Italian witnessed his side lose a league match was a 2-1 defeat to Barcelona in the Clasico at the end of October.
Since then Real has dropped points on just two occasions and another win against Simeone's charges would cement its title ambitions.
Furthermore, Real heads into the encounter on the back of a 6-1 demolition of Schalke in their Champions League last-16 first-leg encounter on Wednesday.
Gareth Bale, Karim Benzema and Cristiano Ronaldo all notched twice in that match, and the Portuguese returns to league action after serving a three-match ban for a red card in the 1-1 draw with Athletic Bilbao at the start of February.
That means Sami Khedira (knee) remains the only absentee for Real, while Atleti have no any fresh injury worries, as they look for a swift response to the 3-0 defeat at Osasuna last weekend.