Mesut Ozil is set to make his first home appearance following his transfer from Real Madrid, while Marko Arnautovic could be handed his first start by Mark Hughes
After an opening-day 3-1 defeat to Aston Villa, Arsene Wenger's side has bounced back strongly with six straight victories in all competitions.
The most recent of those came in a 2-1 success away to Marseille on Wednesday in the club's opening Champions League fixture.
That followed an equally impressive performance in a 3-1 triumph at Sunderland last Saturday, a result that has left the Gunners second in the Premier League.
"We've won the last six games, four of them away from home," Szczesny told Arsenal Player. "We know the momentum is with us. The games are coming thick and fast because we play in every midweek games so I'm sure we can keep that going, keep the momentum going and keep getting results.
"I think it's just the desire of the whole team to defend well. We've been defending really well and then scoring goals on the counter attack."
Wenger has no fresh injury worries, with Santi Cazorla (ankle), Lukas Podolski (hamstring), Abou Diaby (knee), Alex Oxlade-Chamberlain (knee) definitely out, while Yaya Sanogo (back) and Tomas Rosicky (hamstring) remain doubtful.
The return to training this week of Mikel Arteta opens up the possibility of him potentially being involved in some capacity. The 31-year-old midfielder has yet to feature this season due to a quadricep injury, but Wenger revealed on Friday that his "leader" is closing in on a return.
Mesut Ozil could make his home debut after starring against Sunderland, while midfielder Aaron Ramsey will look to continue his strong run of form that has seen him open the season with six goals in all competitions.
Mark Hughes has had an impressive start to his tenure as Stoke manager.
The Britannia Stadium outfit lost its first Premier League game with Liverpool, but has bounced back with wins against Crystal Palace and West Ham before securing a 0-0 draw at home to Manchester City last Saturday.
History, though, is against his side, with Stoke failing to take a single point from five Premier League visits to the Emirates Stadium.
Stoke's last trip to Arsenal ended in a 1-0 defeat in February, courtesy of a Podolski strike.
Centrer back Marc Muniesa remains the only injury doubt for Stoke, but Hughes will be hopeful he recovers from a groin strain to feature.
Marko Arnautovic could make his first start since his transfer-window move from Werder Bremen after the striker caught the eye on his debut as a 70th-minute substitute in the stalemate with Manchester City.