Rampant first half sees Arsene Wenger's s present visitors with insurmountable challenge as recalled Wojciech Szczesny drops clanger to ruin side's unbreached defensive record
Gervinho led the way for Arsenal with a double and Lukas Podolski, Nathaniel Clyne, Theo Walcott all added goals a piece in the rout. Southampton's lone score game from Daniel Fox, though Jos Hooiveld had an own goal.
The Gunners got to a strong start in the first half as Gervinho scored his first goal and Hooiveld and Clyne added a goal each. Fox responded for Southampton but the newly promoted side had no answer for Arsenal in the second half.
Arsenal continued to assert domination in the second half as Gervinho's second and Theo Walcott's late effort made it six.
The result stretched the home side's unbeaten start to the season as Southampton are still to find their first point after rejoining the top flight.
Gunners boss Arsene Wenger was unable to call upon Abou Diaby or Theo Walcott, though the latter made the bench. Wojciech Szczesny was restored to the starting lineup, as Gervinho replaced Olivier Giroud up front and Francis Coquelin came into the centre of midfield.
Saints begun with the same side that battled to a 3-2 defeat against Manchester United, with trio of new signings Gaston Ramirez, Emmanuel Mayuka and Maya Yoshida having to make do with a place on the bench.
Arsenal begun the brighter of the two and their early pressure was rewarded in the 10th minute after Hooiveld turned the ball into his own net as Kelvin Davis could only get a foot to Keiran Gibbs' low, drilled cross from the left byline.
Per Mertesacker tested Davis with a powerful header from Santi Cazorla's looping ball into the box as Arsenal began to assert their dominance, before Gervinho fizzed an effort just wide of the post.
Hooiveld was replaced by Maya Yoshia around the half hour point as Saints fully capitulated, conceding three goals in a matter of minutes.
Steven Davis gave away a needless foul on the edge of the area, allowing Podolski to step up and bend a left footed effort that was well beyond Kelvin Davis' grasp.
Almost immediately after the restart Saints left back Daniel Fox was caught napping and a simple Mikel Arteta lofted pass down the line allowed Gervinho to steam in on goal and smash home at the near post.
Arsenal got their fourth in a manner similar to the game's opener. Another powerful surge down the left from Gibbs saw the full-back whip in a cross that ended up in the Saints net via a wicked deflection off Clyne.
Moments before the interval Wojciech Szcznesy granted the visitors a lifeline, making a total mess of a cross from deep to allow Fox to poke in from yards out.
Rickie Lambert missed a good chance to get his side back with a fighting chance though slotted wide, as Arsenal continued to enjoy the upper hand in the second half.
The Gunners further stretched their lead after substitute Aaron Ramsey made an instant impact, outfoxing Clyne as he burst into the box, only to see his prodded effort rebound off the post to allow Gervinho to bundle home from a couple yards out.
Gervinho and Podolski were replaced to rapturous applause, with replacement Walcott puting the icing on the cake, bending home with his left foot as the visitors' defence made a hash of clearing Thomas Vermaelen's strike.
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