Nigel Adkins' men have lost all three of their opening fixtures and face a Gunners' side buoyed by its victory over Liverpool prior to the international break.
Jenkinson, Vermaelen, Koscielny, Gibbs
Diaby, Arteta, Cazorla
Oxlade-Chamberlain, Giroud, Podolski
Clyne, Hooiveld, Fonte, Fox
Schneiderlin, S. Davis, Ward-Prowse Puncheon, Lambert, Lallana
Arsene Wenger faces an agonizing wait over the fitness of several key players ahead of his side's clash with Southampton.
Theo Walcott has been ruled out with a virus and is likely to be replaced by Alex Oxlade-Chamberlain. Midfielder Abou Diaby, who was injured on international duty with France, could be a doubt after suffering from a small muscular problem.
Wojciech Szczesny looks set to replace Italian goalkeeper Vito Mannone in goal after recovering from injury, but his compatriot Lukasz Fabianski will miss out with a shoulder injury.
For the visitors, club record signing Gaston Ramirez has finally received the all-clear to join up with the squad after an issue with international clearance, but may sit on the bench.
|DID YOU KNOW?|
- Arsenal has scored just two goals in its three Premier League games so far this season, which is the same amount it had scored at this stage last season.
- Germany international Lukas Podolski (pictured right), who joined this Arsenal this summer from FC Koln for 10.9 million pounds, won his 100th cap for his country against Denmark at Euro 2012 at the age of just 27.
- The Gunners have drawn their last three home matches in the Premier League. However, they have also kept a clean sheet in all three of their games so far this season.
- Arsenal has finished at least fourth in the Premier League in every season since the 1996-97 campaign, winning the Premier League title three times under Arsene Wenger.
- Southampton is yet to pick up a point this season in the Premier League, despite having led in two of its three games.
- Despite being bottom of the Premier League, the Saints have scored twice as many goals as Arsenal have (four).
- The south coast club has twice broken its transfer record this summer. It first signed Jay Rodriguez from Burnley for a fee of 7m pounds, and then secured a deal for Uruguayan playmaker Gaston Ramirez from Bologna for 11.8m pounds. Its previous record signing was Rory Delap, who cost 5.3 million pounds from Derby in 2001.
- Southampton has failed to win in any of its last seven encounters away to Arsenal.
- And the Championship winner of 2011-12 also need to tighten up at the back, as it has conceded at least two goals in each of its three games this season.