A mere spectator in the first half, although he would have been relieved to see Kone and Boyce spurn good chances at the far post. Made some impressive catches in the second half but was rarely troubled.
Looked by no means out of his depth on his Old Trafford debut. The Dutchman was always a willing runner to provide an outlet on the left but never ignored his defensive duties, and made one crucial block on Di Santo in the first half. In the second half, he fired across goal to allow Chicharito to poke home before bustling his way past three defenders to open his own account. Only a booking for a late lunge on Boyce tarnished a fine debut.
Strong in the air and on the ball, but looked as though he could be exposed for pace whenever the likes of Maloney or Di Santo could turn and run at him.
Dealt with most of Wigan's aerial threat comfortably, and looked less troubled by Maloney's pace than his defensive partner.
Almost non-existent as an attacking threat in the first half, but became far more adventurous in the second and exposed a tiring Wigan left-flank. Set up Powell for a debut goal.
Combined effectively with Buttner down the left but struggled to find a way past Boyce early on. His link-up play was much brighter in the second as he pushed higher up the pitch. Replaced by Van Persie near the hour mark.
Beat Figueroa all ends up to provide the cross for Scholes' opener. Twice provided the telling ball for Welbeck in the opening spell of the match, the first of which led to the penalty. Fired a great chance over the bar just before half-time, although he could justifiably point to a bobble on the surface.
Became too-often outnumbered in the first half and was guilty of conceding possession a little too frequently, but grew into the game as United began to seize the initiative.
His usual telescopic eye for a pass was slightly off in the first half, but he rolled back the years to mark his 700th club appearance with a simple finish after bursting into the box from deep.
Was fortunate to win a penalty under minimal contact from Al-Habsi, but his close control and hard graft proved a real danger to Martinez's men, a fact underlined when he regained possession in the area in the build-up to Chicharito's goal.
His day threatened to become a bleak one when his early penalty was saved by Al-Habsi, but he atoned with a well-taken finish in the second half and threatened all afternoon with his movement.
Ali Al Habsi
Made a good save from Chicharito's penalty, but could have done more to parry Nani's cross away from danger for United's first and blocked Buttner's effort into his own net from close range. Could do little about Chicharito or Powell's goals.
Dealt comfortably with any threat down the right for most of the first half, but as Rafael became more and more adventurous, he found himself outnumbered at the back. Failed to stop Nani for United's opener.
Put a first-half header narrowly wide, but was too often made to look slow by the pace of United's attackers and should have done better to stop Buttner's run.
Scuffed a shot into the side netting after a promising run into the United area in the first half. Was effective in the first half but, like many of his teammates, became tired in the second period and failed to deal with a resurgent United.
A committed display from the captain, although his efforts to physically dominate the likes of Chicharito resulted in a handful of free-kicks in dangerous positions. He was booked for pulling down the Mexican in the second half.
Industrious and effective in the middle of the park as Wigan nullified Scholes to good effect. Was booked for a frustrated late tackle on Nani, and conceded possession cheaply for United's fourth.
Almost provided a telling assist for Kone as his cross was deflected off Rafael. Proved troublesome in both halves of the pitch in the first 45, but tired quickly and was replaced by Jones in the second half.
Frustrated Scholes and Carrick in the first half but seemed to fade from the action in the second as the hosts often found a way through.
Looked a menace whenever in possession, and bamboozled Scholes in front of the delighted travelling fans in the first half. Unfortunate to be replaced by Gomez with less than an hour played.
Scuffed a great chance late in the first half which could have given his side the lead.His work-rate was impressive throughout but he offered little threat in the second half.
F. Di Santo
Was generally bright with the ball at his feet and he linked well with the likes of Kone and Beausejour. However, whenever Wigan opted for a long ball, he was consistently out-muscled by Vidic and could not relieve the relentless second-half pressure.
Replaced Nemanja Vidic late on as he looks to rebuild his fitness following a lengthy lay-off.
Replaced Ryan Giggs and marked his Old Trafford debut in style, smashing one past Al-Habsi from 20 yards to the delight of his new teammates.
R. van Persie
Linked up well as United's attack became free-flowing, and dispelled any notions that he may still be carrying an injury from international duty with a decent run-out.