Diego Simeone's men can make it four wins out of four on Wednesday and, having only lost once this season, are expected to secure progress.
The Liga high-fliers top Group G after winning their opening three matches and will enter the home fixture against their struggling opponent as red-hot favorites.
Atletico has won 11 of 12 league fixtures this season, helping the club to second place in the table, just one point behind Barcelona.
The club sits five points ahead of city rival Real Madrid, largely thanks to the form of forwards Diego Costa and David Villa.
Costa has been outstanding for Diego Simeone's side, scoring 15 goals in as many appearances in all competitions. His latest effort came in Sunday's 2-0 home success against Athletic Bilbao, when Villa also scored to take his tally to seven.
Costa missed the first two matches of this year's group stage due to a suspension incurred in last season's Europa League, but he scored twice in Atletico's 3-0 win at Austria Vienna last month.
The Rojiblancos have never won four consecutive matches in the Champions League and are aiming to qualify for the knockout rounds of the competition for the first time since the 2008-09 campaign.
Austria Vienna sits at the bottom of Group G with just one point from three matches and the team's league form suggests an upset is highly unlikely.
Although it beat Wiener Neustadt 3-0 on Sunday in the Austrian Bundesliga, the club is fifth after a poor run of results.
Head coach Nenad Bjelica - who will serve a touchline ban for the fixture - saw his side win just one of 12 matches before Sunday's triumph.
A goalless draw against Zenit last month was the first Champions League point won by an Austrian side since 2001 and the team's inexperience is highlighted by the fact that just two of its players - strikers Tomas Jun and Roman Kienast - have played in Europe's premier club competition before this season.
Bjelica will be without Alexander Grunwald and Alexander Gorgon (both knee) and Marko Stankovic (muscular problem).