The Blancos have found life difficult at El Sadar in previous encounters but will be determined to win to keep up the pace with city rival Atletico and Barcelona at the top.
Real Madrid can continue to mount the pressure on La Liga leader Barcelona when the club travels to face struggling Osasuna on Saturday.
Carlo Ancelotti's men have won their last five league games since losing 2-1 to Barca back in October, and sit only three points adrift of the defending champion in third place.However, Real has emerged victorious on only one of its last five visits to El Sadar Stadium in Pamplona and is sure to be tested this weekend.
The club will be boosted by the presence of Cristiano Ronaldo, who made a goalscoring return to action in the Champions League clash with Copenhagen after missing the previous three games because of a thigh injury.
France defender Raphael Varane is still out due to a knee injury, while Fabio Coentrao (thigh) and Sami Khedira (knee) remain on the sidelines.
The home side has endured a dismal campaign so far and sits only one point above the relegation zone going into this game.
Javi Gracia's men have experienced a minor upturn in form in recent times, winning two of their last seven league meetings, but have already lost 10 games and possess the worst attacking record in the division.
Osasuna has scored a mere 11 times in 15 league games, although Gracia would have been pleased with the team's offensive performance in the Copa del Rey meeting with Malaga last weekend, which ended in a 3-3 draw.
Still, Gracia will have to cope without key midfielder Patxi Punal, who is suspended after receiving a straight red card in the 3-0 defeat to Valencia earlier this month.
Attacking midfielder Nino (knee) is doubtful, with Miguel Angel de las Cuevas (elbow) and Sisi (knee) both unavailable.