Both sides still have Premier League glory in their own hands, though victory for the Merseysiders on Sunday would take them seven points clear of Manuel Pellegrini's men.
The Reds have enjoyed a remarkable season, based largely on a stellar attacking unit, while City has been just as impressive, despite its fall to third because of commitments in various cup competitions.
Despite having two games in hand on Brendan Rodgers's men, the gap of four points between the sides means that City can ill afford defeat at Anfield.
With Chelsea lurking in second, two points off the top, Liverpool knows that a 10th straight Premier League win would put it very much in the driving seat for a first title since 1990. However, Rodgers insists that this game is not necessarily crucial in deciding the destination of the trophy, calling on his players to relish the stretch run.
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Strikers Luis Suarez and Daniel Sturridge have been integral to Liverpool's title tilt, contributing 49 of the club's 90 top-flight goals this season.
Indeed, Suarez needs just three more to overtake the record of 31 goals in a 38-game Premier League season, which is held by Alan Shearer and Cristiano Ronaldo.
The Uruguayan's efforts have helped Liverpool eclipse City's own impressive goal tally, with Manuel Pellegrini's side having plundered 84 in its 31 outings.
Sergio Aguero has accounted for 15 of those and Pellegrini has been boosted by the news the Argentine is fit to play at Anfield following a four-week layoff with a hamstring problem.
City's Pablo Zabaleta spoke this week of the importance of his compatriot returning to the fold but the defender also warns that Liverpool's prolific strike force will require close attention.
"Liverpool score a lot of goals — we know they have great players in front with Suarez, [Raheem] Sterling and Sturridge. They are in a great, great moment," Zabaleta told City's official website. "I think we must work really hard not to concede any goa but we have defended well for a few weeks — not conceding many goals — so we have to be confident."
Indeed, City has conceded just twice in its last seven Premier League games and is unbeaten on the road since a shock 1-0 reverse at Sunderland in November. Liverpool, though, has lost just once at Anfield this season and, if it can make it six home wins in a row Sunday, the destiny of the title would remain in its hands.