Brendan Rodgers will be without Steven Gerrard, who is set to miss at least four weeks with a hamstring injury, while Roberto Soldado may start ahead of Jermain Defoe for Spurs
Andre Villas-Boas' charges have hit the target on just 15 occasions in the Premier League this season, the same number Luis Suarez has bagged in the top-flight this term, although the Uruguayan has reached the tally in five fewer games.
But Tottenham's recent record on home soil against Brendan Rodgers' men will give it confidence, with the London outfit having defeated Liverpool in the last six encounters at White Hart Lane in all competitions.
Its last loss in the league came in a humiliating 6-0 drubbing at Manchester City, but Tottenham has bounced back well with a draw against Manchester United and consecutive 2-1 victories on its travels at Fulham and Sunderland.
Tottenham's upturn in form continued in the Europa League on Thursday, as a hat trick from Roberto Soldado helped secure a 4-1 triumph over Anzhi Makhachkala and preserve its 100 percent winning record in Group K.
Villas-Boas will now have to decide whether to keep faith in Soldado, or restore England forward Jermain Defoe to the starting lineup, with the latter starting the last two Premier League games.
Center back Jan Vertonghen will miss out for Tottenham with an ankle injury, while midfielder Christian Eriksen (ankle) and fullback Danny Rose (foot) will undergo late checks as they continue their recoveries.
Defensive duo Vlad Chiriches (knee) and Younes Kaboul (quad), and striker Emmanuel Adebayor (knee) are also injury doubts.
Liverpool occupies second in the league, and is looking for its third consecutive victory in the top flight.
After a disappointing 3-1 loss at Hull City in its last away fixture, Liverpool bounced back with strong home triumphs over Norwich City and West Ham in which the Merseyside outfit scored nine goals.
But Liverpool was dealt a blow ahead of the fixture with the news that influential captain Steven Gerrard will miss at least four weeks of action with a hamstring injury, joining striker Daniel Sturridge (ankle) and defensive pair Sebastian Coates and Jose Enrique (both knee) on the sidelines.
England international Jordan Henderson could deputize for Gerrard in central midfield after overcoming an ankle knock.
One of the most pressing concerns for Rodgers will be shoring up his defense, with Liverpool managing just one clean sheet in their past 12 Premier League matches.
But with Tottenham scoring just seven times at home this campaign - only Aston Villa has fewer with six - Liverpool will be optimistic its defense will not be breached.