Manuel Pellegrini makes his competitive bow in English football, with a host of new signings set to do the same, while Alan Pardew faces a tough task to get a result
The Chilean replaced Roberto Mancini as City boss back in June and he could hardly have asked for a better first competitive fixture if recent history is anything to go by.
Man City's pre-season results
||0-2 v Supersport
||1-2 v Amazulu
||1-0 v South China|
||1-0 v Sunderland
||5-3 v AC Milan
||1-2 v Bayern Munich
||1-3 v Arsenal
Their chances of extending that record are also boosted by the fact that the Magpies head have never enjoyed victory at the Etihad Stadium.
For Pellegrini, the clash represents the first true test of his reign in charge of City and he will be hoping to build on an encouraging preseason that included victory in the Asia Trophy.
However, Newcastle is unlikely to give any quarter - although manager Alan Pardew's selection plans have been hampered by the club's early-season injury list.
Newcastle will be without new signing Loic Remy (calf), while Ryan Taylor (knee) has been ruled out for almost the entirety of the 2013-14 campaign.
And, while Jonas Gutierrez (calf) could return, an injury to Davide Santon (hip) means that Pardew is toying with the idea of handing 21-year-old left back Paul Dummett a daunting debut.
"Davide has a problem and I think he's doubtful for the game," Pardew told reporters. "I gave [Mark] Noble, [Alex] Oxlade-Chamberlain and [Jonjo] Shelvey debuts at 16 so I have no problem with age.
"In terms of where [Dummett] is at and the preseason he has had, he has put himself in real contention, but Man City away would be a tough call for him having not made his debut for us yet.
"You're either ready or you're not and throwing into the deep end sometimes works but up against him would be [Jesus] Navas, who, in my opinion, is probably the best signing of the summer. He's a little bit special.
"That's something we'll think about but, going forward, I'd expect him to make 10 first-team starts this season."
Even without considering his vastly deeper squad, by contrast Pellegrini has few injury worries ahead of City's opener.
Matija Nastasic is likely to be replaced by Joleon Lescott in defense having suffered an ankle injury but the 59-year-old has an otherwise fully fit squad from which to choose.
That means that close-season arrivals Alvaro Negredo, Navas, Fernandinho and Stevan Jovetic could all be handed Premier League debuts.