Marc Wilmots' side are currently second in Group A, tied on points with Serbia and Croatia, after taking four points from their opening two qualifying games.
Mignolet is of the opinion that his side need to pick up points at home, starting with their clash against Craig Levein's men, to avoid a repeat of the disappointment of not qualifying for Euro 2012.
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"It's important in terms of qualification, as is the Serbia match. We play the Scots at home and if we want to win our group we have to win our home games. Hopefully we can do that."
The 24-year-old is targeting a turnaround in the Black Cats' fortunes after the international break, starting with a mammoth Tyne-Wear clash against Newcastle on October 21.
"Some of the guys are away and that's a good thing for them personally to have that experience of being among their international squad and playing games," he continued.
"We can't dwell upon the defeat at Manchester City. We have to forget about it because when we come back we have a big game to play against Newcastle."