The Elland Road outfit host the table-topping Foxes looking to end a woeful run of form that has seen them knocked out of the FA Cup and humiliated 6-0 by Sheffield Wednesday
Nigel Pearson's side have a four-point lead at the top of the table and demonstrated their dominance with a 4-1 victory over Derby County last time out.
When Leicester - boosted by the signing of veteran striker Kevin Phillips on a deal until the end of the season - arrive at Elland Road they will find a Leeds side without a win in their last six games in all competitions and on a run of four consecutive defeats.
The Yorkshire club were dumped out of the FA Cup by League Two Rochdale and then fell to a humiliating 6-0 defeat to Sheffield Wednesday at Hillsborough last Saturday.
Burnley and QPR lead the chase to catch Leicester at the top and both have home fixtures to maintain their winning runs.
Wednesday travel to Turf Moor buoyed by that win over Leeds, while Huddersfield Town make the trip to London to Loftus Road looking for a first away league win since early December.
Derby and Brighton, two of the top six, meet with Steve McClaren's side looking for their first win of 2014, having been unbeaten in December.
Brighton have climbed into the play-off zone thanks to a run of three league games unbeaten, culminating in their 1-0 win over Birmingham City last weekend.
Nottingham Forest will look to close the gap on their fierce rivals when they face Blackburn Rovers at the City Ground, while Bolton Wanderers will be in the way of Reading's push for the top six.
Blackpool's run of eight games without a win has seen them fall from fourth to 14th, but Paul Ince's men can get back on track at bottom club Barnsley.
Ian Holloway's first home game in charge of Millwall sees the visit of Ipswich Town, a club managed by former Millwall boss Mick McCarthy.
Ipswich's loss to QPR ended their eight-game unbeaten run, however McCarthy will be confident given Millwall have not won a league match in the last six attempts.
Fellow strugglers Yeovil Town travel to Birmingham City, while Paul Dickov's Doncaster Rovers host a Wigan Atheltic side brimming with confidence since the arrival of Uwe Rosler.
There will be a mid-table clash at Dean Court as Bournemouth entertain Watford and Charlton Athletic travel to Middlesbrough.