Sheffield Wednesday thumped Yorkshire rivals Leeds United 6-0 to continue their resurgence under caretaker manager Stuart Gray.
First-half goals from Reda Johnson and Atdhe Nuhiu put Wednesday firmly in the driving seat and Matt Smith's red card for a challenge on Johnson early in the second period handed Leeds an uphill task.
Further strikes by Connor Wickham and Chris Maguire, along with a Caolan Lavery brace, ensured that Wednesday wrapped up a memorable win.
Wednesday now sit four points above the relegation zone, while Brian McDermott's men are the same distance from the play-off places on the back of the club's first 6-0 defeat since a 1959 loss to Manchester United.
Promotion candidates Burnley and QPR kept up their pursuit of leaders Leicester City with wins at Yeovil and Ipswich Town respectively.
Leicester had dispatched fourth-placed Derby County 4-1 on Friday but Burnley's reliable strike duo of Danny Ings and Sam Vokes reduced the gap to four points with goals in a 2-1 victory at Huish Park, while second-half strikes from Niko Kranjcar, Gary O'Neil and Armand Traore ensured that Harry Redknapp's men left Portman Road with a 3-1 triumph.
Nottingham Forest failed to capitalise fully on Derby's slip as Bolton defender Matt Mills headed his team to a 1-1 draw at the Reebok Stadium, cancelling out Jamie Paterson's well-taken opener.
The three teams directly below Forest – Brighton, Reading and Blackburn Rovers – all boosted their own play-off hopes with respective 1-0 wins over Birmingham City, Watford and Doncaster Rovers.
Wigan Athletic's new lease of life under manager Uwe Rosler means that they are another team with play-off aspirations, and Marc-Antoine Fortune and Jordi Gomez struck either side of an unfortunate Elliott Ward own-goal to condemn Bournemouth to a 3-0 loss at the DW Stadium.
A late Mustapha Carayol double earned Middlesbrough a 2-0 win at Bloomfield Road and piled further pressure on Blackpool manager Paul Ince, who has overseen eight defeats and a draw in his team's last nine matches.
Huddersfield's new record signing Nahki Wells climbed off the bench to net a last-minute winner, meaning that new boss Ian Holloway headed back down south with a 1-0 defeat from his first game in charge of Millwall.
Barnsley remain bottom of the Championship and five points from safety after their game at Charlton was postponed due to a waterlogged pitch.