The Stoke City midfielder is ineligible to face former side Aston Villa, so the Potters boss is hopeful his on-loan winger can deputise in midfield
The winger, who is on a season-long loan from Liverpool, has not featured for the Potters since the 1-1 draw with Swansea City in mid-February due to a knee injury - but could return at Villa Park this weekend.
Should Assaidi be available, he is likely to take the place of Ireland, who is ineligible to face the side he left to join Stoke.
"Villa stipulated that they wouldn't want Stephen to play against them when we agreed the deal in January," Hughes revealed.
"I can understand that to be honest but it is still a disappointment to be without him because he was exceptional last weekend.
"We are waiting on Oussama Assaidi at the moment. He has trained again this week and is progressing.
"We just need to make sure that he is fully ready to come into the side and that is what we will be looking into over the next 24 hours or so."
Stoke currently sit in 11th with 34 points and would leapfrog Villa with a victory on Sunday.