A family bereavement means the centre-back will not feature at the KC Stadium as Alan Pardew's men look for back-to-back Premier League wins for the first time in 2014
The Argentina international has been given permission to return to South America following the news.
Newcastle revealed Coloccini's absence on Friday, posting a short statement on their official website.
It read: "Newcastle United captain Fabricio Coloccini will not be involved in Saturday's Barclays Premier League fixture at Hull following a family bereavement.
"The centre-back has been allowed to return home to Argentina to spend time with family rather than make the trip to the KC Stadium."
Coloccini only returned from a knee injury last weekend, making his 17th Premier League appearance of the season in the Magpies' dramatic late 1-0 win over Aston Villa.