Rooney will also be doubtful for the following weekend's clash with Chelsea after being sent away for a break in order to get over the groin injury he has been carrying since December.
"We’ve sent Wayne away on a hot-weather break, his groin hasn’t quite recovered yet," Moyes told reporters. "We’ve sent our fitness coach with him, he’s away with his family so we will give Wayne a bit of a break.
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"It’s probably the right time. We’ve given it a chance to try to heal, but we thought the best thing we can do is let him go and work in some warmer weather with one of the coaches and spend some time with his family. Hopefully it will make him feel better."
Moyes also revealed that Van Persie is not quite match fit, after Goal revealed on Thursday that the Dutchman is back in Manchester following some recovery work in the Netherlands.
"Robin is not going to be available yet, he’s going to be a little while but we’re doing everything we can to get him back quickly," he added.
Moyes has been urged to spend money on reinforcing his squad this month, but while he did not rule out making any signings he did once again urge caution.
"The plans and the decisions won’t change," he continued. "We’ve said that we can go and get targets but it’s difficult to get them at this time. I’ve not said we wouldn’t be doing it but I’ve also said that it’s difficult."
Nemanja Vidic's agent revealed earlier this week that the Serb was unlikely to extend his deal at Old Trafford, but Moyes says the club hope to tie him down.
"There are plans there, the chief executive and myself are talking all the time and we're talking to the players. If there's any news to give you we will give it to."
The United boss has come under pressure after guiding his side to three consecutive defeats, but he insists the players have been performing well and that their confidence has not been knocked.
"Obviously if you're not winning it can affect you, but prior to that we had won six games and we weren't talking about confidence after that. But it can happen, you can lose games in football and we ill try to get back into winning ways and get three points.
"I think a lot of the performances have been fine. I think decisions have gone against us which haven't helped but I think we've played pretty well and we just need to try to be a bit more clinical in the final third, to make things count. All the things you would look for in the stats are all pretty good but at the end of the day the only stats that matter is how many goals you score.
"If you go into football management you're going to lose games. I don't know any football manager who hasn't lost any games, so you have to go through it a few times in your career. I've had it a few times and we've having a difficult time just now."