With Victor Wanyama, Nathaniel Clyne, Luke Shaw and Artur Boruc all absent, the Saints have taken just two points from a possible 18 to see them drop from third place to ninth
A 3-2 defeat to Tottenham on Sunday extended Southampton's winless run to six matches, having taken two points from a possible 18.
|16/1||Southampton are 16/1 with BetVictor to finish in the top six|
"We're going through a very tough time at the moment," he told reporters.
"I am concerned by the run, our goal is to return back to defensive solidarity.
"We're lacking a lot of players. Players are going through different injuries and illnesses.
"I don't want to talk about one player. It's not about one player missing at the moment. It would be unfair to talk about the players that are missing."
Southampton face Cardiff City and Everton before the end of the year, with Chelsea visiting St Mary's Stadium on New Year's Day.