The Scot believes that Manuel Pellegrini's men need victory to keep in touch at the top of the Premier League and says that Arsenal are his favourites to win the title
The two teams face each other at the Hawthorns, with the visitors going into the game six points behind leaders Arsenal, who take on Hull City at the Emirates Stadium.
City have won just once away from home this season in the Premier League and Clarke says that Manuel Pellegrini will be expecting all three points against the Baggies.
"I'm lucky enough to have been in a position at Chelsea where you know what you have to do to keep in touch at the top of the league," he told the club's official website.
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West Brom have already beaten Manchester United this season, as well as holding both Arsenal and Chelsea, and Clarke is looking forward to facing City.
"We've a really good home game against one of the sides that will compete for the title, which are the type of games we like, we look forward to, with a good atmosphere," he continued.
"It's been quite a strange league this year in that some of the so-called bigger teams have dropped points against sides they wouldn't have expected to drop points against.
"Man City at home have been a different team to Man City away, that's clear. They've four points from six away games, which is not title-winning form, but it's something they'll address in the coming months."
The Scot also feels that, while City will be fighting for the title this year, they are no longer favourites to win the league.
"If you'd asked me at the start of the season, I would have said: 'Yes, Manchester City are title favourites'," Clarke remarked, "but, this far into the season, I'd say Arsenal. They look a good team who deserve to be where they are, they've a nice little gap at the top.
"Manchester City will be one of the teams competing for the title but, at the moment, Arsenal are in a good position."