Having previously guided Blackburn to victory at Old Trafford, the former United striker has set his sights on ending the Potters’ 30-year wait for a win over the champions, who have won just one of their four home games in the Premier League this season.
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"Historically, Stoke's record hasn't been great at Old Trafford, but sooner or later that has to change.
"West Brom and Southampton have gone there and caused problems, and given the way we are playing away from home I fully expect us to worry them.
"We have played better away from home than we have at home this season, and we want that to continue at the weekend.
"You can't go to Old Trafford and be apprehensive, you have to go there and give it a real go - and that is what we will do.
"There are areas for us to exploit, and if we can do that and restrict them at the other end, I am sure that we can get a result."
Despite their hosts' difficult start to the season under David Moyes, Hughes insists his team cannot afford to underestimate the quality they are up against.
"They are a little bit adrift at the moment, but if you ever question Man Utd, more often than not they will hit back with the answers," he continued.
"The likes of Rooney and Van Persie can win game on their own, so we have to look to keep them quiet, as we do with a number of others."