In the game of the weekend, Manchester City play host to neighbours Manchester United, while the west London derby takes place as Fulham travel to Chelsea, with Jose Mourinho's side looking to end a run of three straight defeats in all competitions.
Meanwhile, Arsenal host Stoke after their impressive away win against Marseille while league leaders Liverpool welcome Southampton to Anfield - and, of course, former Reds midfielder Didi Hamann predicts his scores for the week.
||3 CORRECT 1 PERFECT 6 WRONG
Last time out, Didi scored four out of ten, with a perfect prediction for Tottenham's 2-0 victory over Norwich. Not bad, but not as good as Gus Poyet who still leads the way.
Didi's back again this week. Can he do any better? He has had his say, and now you can too! Leave your predictions in the comments below and vote on how you think he will fare.