The Hammers are due to move into the Stratford-based arena in the 2016-17 season and their co-chairman believes it will help the east London club gain ground on their rivalsWest Ham co-chairman David Gold is hopeful that the club's move to the Olympic Stadium will have a drastic impact on their fortunes.
The Upton Park club were handed a 99-year lease by the London Legacy Development Corporation in March and are due to move in to the Olympic Stadium in time for the 2016-17 Premier League campaign.
West Ham have not won a major trophy since their FA Cup triumph in 1980, while London rivals Arsenal, Chelsea and Tottenham are all well-established top six clubs.
But Gold feels the move to a new stadium will enable West Ham to catch up with their neighbours.
"It's an opportunity. It's an opportunity that comes once in a lifetime," Gold said.
"We have always been in the shadow of Arsenal, Chelsea and Tottenham.
"There's no denying it, they have always been bigger clubs, they have had bigger stadiums and that's been the key.
"Our stadium all the way through the generations has never matched those three clubs.
"Therein lies the difficulty because we are probably not that far behind in terms of fan bases.
"You could argue Arsenal have reached their potential with their new stadium and everything. You could argue that with Chelsea with the huge money created by their owner.
"With West Ham we are now on our move, our surge."