Africa's governing body says that teams from the three countries will have to play their home games, including qualifiers for the Cup of Nations, in neutral venues
All three are due to participate in the 2015 Africa Cup of Nations qualifiers set for early September. Their opponents, notably Togo, had recently complained to Caf to move the matches away from those countries due to the threat of the deadly disease, which has devastated regions of Western Africa in recent weeks.
"Caf maintains all its fixtures on the continent except in Guinea, Sierra Leone and Liberia, where the Ebola disease has registered a high record of infection," Caf said in a statement on Tuesday.
The measure will remain in force until mid-September and will be reviewed in accordance with the health situation in those countries, the organisation added said.
Guinea's game against Togo in Group E of the qualifiers was set to be held in their capital of Conakry on September 5, while Sierra Leone were to host DR Congo in Group D on September 10.
The Sierra Leone FA is currently in talks with Ghanaian officials to play their home matches in Accra, according to sources in Freetown.
The Ebola virus has infected close to 2000 people in the three countries, causing 373 deaths in Guinea, 323 in Liberia and 315 in Sierra Leone. There is no definite cure, according to the World Health Organisation, although untested treatment methods have recently proved effective in two cases affecting Americans.