Liberian striker Eddy Foday Boakay hit five goals as the Indonesian side routed the Myanmar club at home to seal progress to the quarter-finals
The Indonesian side were the favourites to progress against their Myanmar opponents in their Round of 16 tie at Mandala Stadium, but most would not have foreseen such a score.
The victory was the largest ever in the knockout rounds of the competition, eclipsing Vietnamese side Binh Duong's 8-2 triumph over Malaysian club Kedah in 2009. It was also the second time a team had scored nine goals, with Uzbekistan's Nasaf the first to achieve the feat with a 9-0 win against India's Dempo SC in 2011.
The total of 11 goals also matched the previous-highest in the competition, which came when Hong Kong's Sun Hei beat Vietnam's Hoa Phat Hanoi 7-4 in 2007.
Liberian striker Eddy Foday Boakay and Yustinus Pae gave the hosts a quickfire 2-0 lead in the first 10 minutes, only for Cezar Augusto and Kyaw Ko Ko to draw Yangon level within the next 10.
But it was all Persipura after that, with Boakay firing in another four goals to become the first player to score five goals in the AFC Cup. Ian Kabes bagged a brace and Titus Bonai grabbed the other goal in an astonishing victory.
It is only Persipura's second appearance in the AFC Cup, after they bowed out in the quarter-finals during their debut in 2011, and they will hope to progress further this time round.