Spurs go to the Stade de Gerland with a slender 2-1 first-leg lead courtesy of two brilliant free kicks at the end of each half from Gareth Bale.
But, with home advantage and an away goal thanks to Samuel Umtiti's wonder-strike at White Hart Lane, Garde believes that his team can overcome the north London club.
|20/1||Lyon are 20/1 with Coral to beat Tottenham 3-1 in the Europa League second leg
"We need to be patient. We have 90 minutes to qualify. It will be difficult but we can try to close them down and try to cut out their speed.
"To be able to qualify in front of the home fans would be exciting. We won last weekend [4-0 away to Bordeaux] so we have a better mentality now."
Tottenham manager Andre Villas-Boas is expecting a stern test in France but has faith in his side's ability to preserve their lead.
"We face a tough, tough team, it will be difficult for us, but we are focused," the Portuguese told reporters.
"Lyon will be up for it. They have recognised that we are good away from home and we expect a tough match. They have a lot of experience in Europe but we have confidence."