The Spurs centre-back withdrew from Sunday's Premier League defeat by Newcastle with a suspected broken nose and will play no part in Romania's two-legged tie against Greece
|9/1||Greece are 9/1 with BetVictor to beat Romania 2-0 in the first leg|
When asked about Chiriches's injury after the game, manager Andre Villas-Boas told the press: "I think he broke his nose."
The Romanian Football Federation confirmed in a statement on Monday that the former Steaua Bucharest man, who has 22 caps to his name, would not be fit to feature in either match against Greece.
Dinamo Bucharest's Dragos Grigore has been named as a replacement for the 23-year-old.
Romania play the away leg of their tie with Greece in Piraeus on Friday, with the return match taking place in Bucharest four days later.