The Premier League pair were handed tough quarter-final ties against Paris Saint-Germain and Bayern Munich but are they capable of going through to the last four?
Chelsea and Manchester United were both handed tricky ties in the quarter-finals of the Champions League but are they capable of going through?
Chelsea were the sixth team drawn by Portugal legend Luis Figo in Nyon on Friday, where they were paired with a Zlatan Ibrahimovic-inspired PSG, who made light work of Bayer Leverkusen in the last round, winning 6-1 on aggregate.
And you could almost hear the gasps from Old Trafford after it was confirmed that United would face the might of Bayern in the quarter-finals, with the German side hot favourites to lift the title for a second year running.
Arsenal produced a valiant display at the Allianz Arena but were knocked out at the last 16 stage by the Bundesliga giants and David Moyes will know his side will have to be at their very best over both legs to stand any chance of going through.
So can they do it? Will both Premier League sides be in the hat for the semi-final draw? Could both be dumped out at the same stage or will just one of the two go through? Have your say by posting in the comments section below and make sure you cast your vote in the poll!