Goal exclusively revealed on Tuesday that the playmaker was set to return to first-team training after a month out with a calf injury sustained in the 5-2 win over CSKA Moscow.
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"I think on Monday David Silva will be ready," Pellegrini told reporters. "We’ll see after this weekend and how he is then.
"Stevan Jovetic and Matija Nastasic are also still out."
A 3-2 win over West Brom on Wednesday was just City's third away triumph of the season, and Pellegrini hopes the momentum can be carried into the clash at the Stadium of Light.
He continued: "It was an important three points for us at West Brom. We must continue that against Southampton."